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The OTR and GHSR are
2022-08-17
The OTR and GHSR are known to play similar roles in centrally regulated behaviours, where the OTR is implicated in mood, sociability and appetite regulation (Morton et al., 2012; Myers et al., 2014; Sala et al., 2013; Lukas et al., 2011; Slattery and Neumann, 2010), with the GHSR primarily involved
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In this study we saw change
2022-08-17
In this study, we saw change in GHS-R1a mRNA expression in fasting condition. It is noteworthy that changes in ghrelin and GHS-R1a mRNA expression synchronized in organs were examined. In the Ac-DEVD-pNA and pituitary, gene expression increased 4days after fasting, and the increased level declined u
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br Materials Aspergillus oryzae GS
2022-08-16
Materials Aspergillus oryzae βGS (8.4 U mg−1 solid) was obtained from Sigma-Aldrich Chemicals Co. (USA). o-Nitrophenyl β-d-galactopyranoside (ONPG), sodium carbonate, zinc chloride, manganese chloride, calcium chloride and potassium chloride were procured from Sisco Research Laboratories (SRL), M
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The differences in metabolites fermentation characteristics
2022-08-16
The differences in metabolites, fermentation characteristics in skim milk, and the use of lactose revealed by principal component analysis are shown in Figure 3C. Notably, D-XJ4–12 appeared to be isolated from the rest of the strains mainly due to its lack of ability to use lactose. Lactococcus lact
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In the last thirty years
2022-08-16
In the last thirty years, accumulating data have addressed a role for GABA in the modulation of gastrointestinal (GI) functions via its possible involvement in the circuitry of the enteric nervous system (ENS). The ENS is a complex neuronal network located within the gut wall, capable of regulating,
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Senger et al performed a retrospective review of
2022-08-16
Senger et al. performed a retrospective review of 17 patients with ICH on dabigatran or rivaroxaban who received 4F-PCC. Eight patients had a traumatic Clindamycin HCl injury (TBI) and nine patients had a spontaneous ICH. Nine patients had a devastating outcome, including severe neurologic deficits
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br STAR Methods br Acknowledgments We thank P Adler V
2022-08-16
STAR★Methods Acknowledgments We thank P. Adler, V. Riechmann, N. Tapon, E. Knust, the Vienna Drosophila RNAi Center, the Australian Drosophila Research Support Facility (www.ozdros.com), the Bloomington Drosophila Stock Center, and the Developmental Studies Hybridoma Bank for D. melanogaster s
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An important aspect of macrophage biology highly
2022-08-16
An important aspect of macrophage biology, highly influenced by HO-1 activity, is macrophage polarization. The broadest classification, based on the in vitro stimulation, surface marker expression, and inflammatory cytokines production, describes macrophages as classically activated, proinflammatory
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Aldicarb Spatial localization of zGC and zGCAP transcripts b
2022-08-16
Spatial localization of zGC and zGCAP transcripts by in situ hybridization was detected in the ONL. No transcripts were detected in the outermost periphery of the photoreceptor cell layer adjacent to the marginal zone. This region is described as the area of cone genesis and maturation [29], which f
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HSOR belonging to the aldoketo reductase superfamily is
2022-08-15
3α-HSOR, belonging to the aldoketo reductase superfamily, is a rate-limiting enzyme for the synthesis of 3α-reduced steroids, such as allopregnanolone and tetrahydrodeoxycorticosterone. 3α-HSOR was extensively expressed in the spinal dorsal horn and was upregulated following peripheral nerve injury,
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Excessive extracellular glutamate can be removed
2022-08-15
Excessive extracellular glutamate can be removed from Tovok receptor interstitial fluids to the blood plasma for the maintenance of proper extracellular glutamate homeostasis in the mammalian central nervous system [[5], [6], [7]]. The glutamate concentration in the blood plasma increases in case o
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br Introduction Prostate cancer is the most commonly diagnos
2022-08-15
Introduction Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in men in the United States, accounting for about 30,000 cancer deaths annually [1]. Epidemiological studies that show geographical variations in prostate cancer incidence and mortalit
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In the present study compared
2022-08-13
In the present study, compared to diabetic control rats, hepatic glucose-6-phosphatase activity was significantly decreased in both SE and METF treated diabetic animals, with the latter producing greater reduction in glucose-6-phosphatase activity. This observation is consistent with the claim of Ta
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Recently Bristol Myers Squibb and Merck reported
2022-08-13
Recently, Bristol-Myers Squibb and Merck reported their GPR40 agonist research focused on the modification of α,β-position of phenylpropionic UCB 35625 derivatives. For example, in recent published patent applications, Bristol-Myers Squibb claimed the pyrrolidine and dihydropyrazole GPR40 agonists
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Introduction RNA splicing occurs in the nucleus
2022-08-13
Introduction RNA splicing occurs in the nucleus when noncoding sequences (introns) are removed from the pre-mRNA transcript and coding sequences (exons) are joined to form a mature mRNA [1,2]. This reaction is catalyzed by a multiprotein complex called spliceosome. The spliceosome consists of five
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