• In this study we found that ACL silencing is sufficient

  2024-01-27

  

  In this study, we found that ACL silencing is sufficient to impair myoblast differentiation and that this effect is accompanied by a decrease in MYOD early in the myogenic process and by a subsequent decline in fast MyHC protein DMAT mg at a later stage of differentiation (Figure 4J). Furthermore,

• br Asthma The chronic airway inflammatory disease asthma

  2024-01-26

  

  Asthma The chronic airway inflammatory disease LY2940680 is associated with enhanced levels of exhaled NO generated by iNOS in the airway epithelium [12]. In asthmatic patients local and systemic changes in iNOS, peroxynitrite, arginase, ADMA and arginine levels have been observed and are associ

• TUNEL assay Apoptotic DNA fragmentation in cells

  2024-01-26

  

  TUNEL assay. Apoptotic DNA fragmentation in PF-431396 was measured using a commercially available TUNEL assay kit (Thermo Fisher). Frozen cells were fixed with 10% paraformaldehyde/PBS. Apoptosis was determined by staining the 3′-OH ends of fragmented DNA with biotin-dNTP using DNA I klenow fragmen

• br Materials and methods br Results br

  2024-01-26

  

  Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino SW033291 sequence identity among these species is not high (38–52%), our synteny analysis clearly indi

• It is noteworthy that in both cases

  2024-01-26

  

  It is noteworthy that in both cases there is a higher risk for prematurity [44], [61], [97], [98] and for deliveries of newborn small for GA [89], [95], [97], [98]. sFlt-1:PlGF has been showed to be inversely correlated with GA at birth, since 86% of pregnant women who gave birth at Ifosfamide of r

• lamotrigine br Acknowledgements This work was supported

  2024-01-26

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (Nos. 21376172, 21528601 and 21621004) and the Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission (Contract No. 16JCZDJC32300). Introduction Alzheimer’s disease

• Our results lead to the discovery and characterization of Vv

  2024-01-26

  

  Our results lead to the discovery and characterization of VvAAT2, a gene potentially involved in acetate accumulation in grape berries discovered through amino-acid feeding experiments. Incubation with exogenous amino acids has also been a key in the discovery of new genes affecting fruit aromas [13

• Since the publication of the guidelines data

  2024-01-26

  

  Since the publication of the 2011 guidelines, data have continued to accumulate indicating that the cognitive decline in AD occurs continuously over a long period [6–8], and that progression of biomarker measures is also a continuous process that begins before symptoms [9–14]. Thus, the disease is n

• In the QFP rs T allele

  2024-01-26

  

  In the QFP, rs2269657-T allele showed a significant correlation with reduced plaque density in frontal cortices (Table 2), strengthening the association with amyloid pathology. The same 7545 region was shown to exhibit a statistically significant reduction of SREBF2 mRNA levels in rs2269657-T carri

• With regard to the correlation between rearrangements and

  2024-01-26

  

  With regard to the correlation between -rearrangements and thromboembolic events, Zer et al. reported a VTE rate of 36% in a cohort of 98 patients with ALK-positive NSCLC. Of note, VTE was also associated with shorter overall survival (HR: 5.71, =0.01) . Only few others have investigated NSCLC drive

• The random zero offset of accelerometer and gyroscope estima

  2024-01-26

  

  The random zero offset of accelerometer and gyroscope estimated by two-step observation update Kalman filter are shown in Table 2, one group of estimated results is shown in Fig. 3. Contrast with the data from Eq. (23) and the ones from Fig. 3 and Table 2, it can be seen that the random zero offset

• There is a growing literature

  2024-01-26

  

  There is a growing literature on ABCA2 expression in human biopsies, where it has been described as a potential biomarker of leukemias. In childhood T-cell acute lymphoblastic leukemia, ABCA2 and ABCA3 were expressed at high levels, which upon treatment with methotrexate, vinblastine and doxorubicin

• The results show that a tonic action of ACh on

  2024-01-26

  

  The results show that a tonic action of ACh on respiration is lacking. However, it is clear that muscarinic cholinergic mechanisms can modulate both eupneic breathing and the cough reflex. When these mechanisms are brought into action is obscure and only tentative proposals can be advanced. ACh in t

• Moreover showed reduction in fibroblast growth factor induce

  2024-01-26

  

  Moreover, showed 73% reduction in fibroblast growth factor–induced neovascularization in a mouse corneal micropocket assay at a dose of 100mg/kg and 50% reduction at 50mg/kg. Both results were highly statistically significant (Panti-Axl Volasertib have recently shown only moderate efficacy (40% in

• From an historical perspective ligands for GPCRs adrenaline

  2024-01-25

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, Meptazinol HCl or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands w

14955 records 177/997 page Previous Next First page 上5页 176177178179180 下5页 Last page