• Notably our preliminary results confirmed that

  2025-02-06

  

  Notably, our preliminary results confirmed that fluoxetine (SSRIs, 5–10 mg/kg) and duloxetine (SNRIs, 5–10 mg/kg) could not enhance memory function in the novel object recognition or step-down passive avoidance tasks (data not shown). In the present study, we also found that vilazodone showed had no

• br Author contributions br Conflict of interest br

  2025-02-06

  

  Author contributions Conflict of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81502276), Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province (A2017013), the Natural Science Foundation o

• Functional implications notwithstanding the intermolecular

  2025-02-06

  

  Functional implications notwithstanding, the intermolecular contact appears to shield the Y361 side chain (Fig. 3) from being accessible for regulation by phosphorylation/dephosphorylation as has been proposed [18,19]. It is, therefore, likely that Src kinase and PTP1B phosphatase bind to an AROM mo

• In a study highlighted the

  2025-02-06

  

  In 2010, a study highlighted the usefulness of arginase-1 as a sensitive and specific marker of hepatocytic differentiation for diagnostic pathology [9]. Subsequent studies have validated the high sensitivity and specificity of arginase-1, in particular its added value in evaluating poorly different

• br Experimental section br Acknowledgements This work was fu

  2025-02-05

  

  Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.

• Introduction Alzheimer s disease AD is a complex neurologica

  2025-02-05

  

  Introduction Alzheimer's disease (AD) is a complex neurological disorder characterized by a progressive dementia resulting from synapse failure (Selkoe, 2002, Tanzi, 2005). The amyloid hypothesis maintains that the pivotal event in AD is the production of amyloid-β (Aβ) peptides following the prote

• In another study Yerra and Kumar used streptozotocin to

  2025-02-05

  

  In another study, Yerra and Kumar (2016) used streptozotocin to induce diabetic neuropathy in rats. Mechanical/thermal hyperalgesia, motor/sensory nerve conduction velocities (MNCV and SNCV) and sciatic nerve blood flow (NBF) were evaluated. In vitro studies of Neuro2a (N2A) cell culture were perfor

• Decrease in soluble protein content in diabetic lenses compa

  2025-02-05

  

  Decrease in soluble protein content in diabetic lenses compared with those in control lenses in present study could be due to leakage of proteins and insolubilization. T. purpurea treatment could increase the levels of soluble proteins in diabetic lenses may be by preventing cross-linking/aggregatio

• Adenosine is an endogenous nucleoside that plays pivotal rol

  2025-02-05

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the Norcuron and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors

• br Introduction Epilepsy is characterized by spontaneous

  2025-02-05

  

  Introduction Epilepsy is characterized by spontaneous recurrent seizures and represents one of the most frequent neurological diseases affecting about 60 million people worldwide (McNamara, 1999). It is estimated that up to 50% of all cases are triggered by “initial precipitating injuries”, such

• m-Chlorophenylbiguanide hydrochloride For comprehensive unde

  2025-02-05

  

  For comprehensive understanding of actin-myosin XI as a control network, it will be necessary to determine the functions of all the myosin XI and m-Chlorophenylbiguanide hydrochloride isoforms. However, it is difficult to reveal the function of individual myosin XI isoforms because most myosin XI s

• Our second patient years old male a

  2025-02-05

  

  Our second patient, 42years old male, a farmer, was all right when he went to sleep, but noticed drooping of eyelids and swallowing difficulty when he woke up. He later developed flaccid weakness of all four limbs and was quadriplegic when he was wheeled into the emergency room. He was tachypneic an

• What can we learn about the

  2025-02-03

  

  What can we learn about the anticancer therapeutic efficacy of Aurora kinase inhibitors from our experience with the Bcr-Abl inhibitors and the long term clinical consequence of their use in treating leukemias? As discussed, all Aurora kinase inhibitors developed to date are ATP-competitive inhibito

• As shown in B the recombinant human LOX nM

  2025-02-03

  

  As shown in B, the recombinant human 15-LOX-1 (30nM) showed a time-dependent increase in fluorescent signal, and signal development was almost completed within 20min in the presence of 50μM arachidonic Gastrodin and 5μM DHR. For both purified enzyme and cell lysates, the enzyme activities disappear

• br Introduction Melatonin N acetyl methoxytryptamine is a

  2025-02-03

  

  Introduction Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone which is mainly secreted from the pineal gland. Melatonin is a highly conserved molecule present not only in vertebrates but also in nonvertebrates such as bacteria, protists, fungi, macroalgae, and plants (Cecon et al., 2017

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